I have smoked weed from 15 to my present age (62). I also take Xanax several times daily, by prescription. A lot depends on if you have smoked long enough to have reached a “tolerance” level. ive mixed xanax with weed once and it somewhat lessened the effect but it was still really fun. if youre getting anxiety just after smoking, i would say smoke more slowly (smaller joints/bowls) and leave a few minutes in between hits. Of course not. Weed has never killed anyone, however Xanax has. Also it depends how much xanax you’re talking. If you only take, say, 2–4 mg you should be fine. As a newbie I'd take 3 - 4 mgs and see how that is. Ideally I'd smoke some weed with it, the xanax buzz by itself isn't mind-blowing, but its nice. You should not use Xanax if you have narrow-angle glaucoma, if you also take itraconazole or ketoconazole, or if you are allergic to Xanax or similar medicines, such as chlordiazepoxide (Librium), clonazepam (Klonopin), clorazepate (Tranxene), diazepam (Valium), lorazepam (Ativan), or oxazepam (Serax). just popped 0.75mg of xanax && feeling super good thinking of having a J in a bit (not too much, just a tad) as I usually get a little anxiety. If i were you i would take 0.5 mg to start with and wait like caco2521 said and take another 0.5mg to feel really relaxed and save the other half for the train ride this way you know what to expect during the ride instead of doing it for the first time on a 27 hour train ride i mean nothing bad will happen you will just feel tired and kind of a drunk feeling without the spin and hangover part He explains what happens to someone's brain when they take Xanax. He also discusses some of the long-term side effects of using Xanax. Following is a transcript of the video. DON'T TAKE XANAX! , I AM saying, that if that supply ever dries up, you'll wish you were dead by the end of day 3-4 of withdrawls, and it'll just get worse and worse till about the second week mark. Forget this fuckn bullshit '3 day hump' shit, it takes 3 days with benzos to even START really feeling the withdrawls.